Females were significantly more likely to attain MCID than male in COPD patients (adjusted odd ratio (aOR) = 1.93, adjusted 95% confidence interval (a95%CI) = 1.09–3.42, p = 0.024). Overall, 341 (49.1%) patients attained the MCID of CAT and the incidence of exacerbation during follow-up was 22.3%. Results: In 695 patients, the mean age was 62.5 ± 8.2 years, with a mean CAT score of 15.1 ± 6.0. We mainly assessed the MCID and the incidence of exacerbations at the 6 months follow-up. Minimum clinically important difference (MCID) was defined as attaining a COPD assessment test (CAT) decrease ≥2. Baseline data were collected at the first visit. A face-to-face interview was conducted to collect data. Patients and Methods: We conducted a multicenter prospective longitudinal study that was carried out in 12 hospitals in China from December 2016 to June 2021. Purpose: This real-world study evaluated the effectiveness of different inhalation therapies in patients with symptomatic chronic obstructive pulmonary disease (COPD) in China and also explored the relevant factors that influence the effectiveness of inhalation therapy. 5Division 4 of Occupational Diseases, Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, China.4Department of Respiratory Medicine, The First Affiliated People’s Hospital, Shaoyang College, Shaoyang, China.3Department of Pulmonary and Critical Care Medicine, Zhuzhou Central Hospital, Zhuzhou, China.2Department of Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.1Department of Pulmonary and Critical Care Medicine, Research Unit of Respiratory Disease, Diagnosis and Treatment Center of Respiratory Disease, The Second Xiangya Hospital, Central South University, Changsha, China.Wei Cheng 1, Jiaxi Duan 1, Aiyuan Zhou 2, Yiyang Zhao 1, Rong Yi 3, Yi Liu 3, Dingding Deng 4, Xin Li 5, Yuqin Zeng 1, Yating Peng 1, Qing Song 1, Ling Lin 1, Min Yang 1 and Ping Chen 1*
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